HOPES: The Power of Interconnectedness

HOPES Power of Interconnectedness

Clinical and observational studies complement each other with differing strength in internal validity and applicability, systematic review statistically pools both types of studies to provide increased power to make healthcare decisions, and modeling estimates final health outcomes from intermediate outcomes and epidemiologic links in an analytic framework. Methodologists test and devise new methods while clinical researchers utilize big data to answer clinically relevant questions. HOPES was envisioned to accelerate methodological advancement (NIH) and provide broad based outcomes research solutions to funders (foundations (PCORI), federal government (AHRQ), and industry (pharmaceutical and device industry)). Success in one area can uniquely position HOPES to compete for funding in other areas by anticipating future directions and prospectively fashioning solutions.